Описание спб института биорегуляции и геронтологии. Описание спб института биорегуляции и геронтологии Научно-исследовательские подразделения СПБ Института биорегуляции и геронтологии

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Санкт-Петербургский Институт биорегуляции и геронтологии основан в 1992 г. с целью реализации задач в области геронтологии и внедрения в медицинскую практику результатов экспериментальных и клинических исследований нового класса лекарственных препаратов - пептидных биорегуляторов, созданных в научно-исследовательской лаборатории биорегуляторов Военно-медицинской академии им. С.М. Кирова.

В 2001 г. Институт вошел в состав Северо-Западного отделения Российской академии медицинских наук.

Деятельность Санкт-Петербургского института биорегуляции и геронтологии СЗО РАМН направлена на решение следующих задач:

проведение фундаментальных научных исследований, совершенствование методов диагностики и прогнозирования заболеваний, развитие научно-производственных программ в области биорегуляции и геронтологии
разработка, клиническое изучение, производство и внедрение в клиническую практику лекарственных средств, современных диагностических и лечебных технологий для ранней диагностики, профилактики и лечения возрастной патологии;
распространение и пропаганда научных знаний в области биорегуляции и геронтологии (организация научных конференций, издательская деятельность и т.д.)
изучение свойств и механизмов действия пептидных биорегуляторов, влияние пептидных биорегуляторов на механизмы старения
разработка и внедрение в медицинскую практику новых пептидных биорегуляторов для профилактики преждевременного старения и развития возрастной патологии.

Руководство института

Хавинсон Владимир Хацкелевич — директор Санкт-Петербургского института биорегуляции и геронтологии, президент Европейского регионального отделения Международной ассоциации геронтологии и гериатрии (МАГГ), вице-президент Геронтологического общества Российской академии наук, Главный геронтолог Санкт-Петербурга, профессор, доктор медицинских наук, член-корреспондент РАМН, заслуженный деятель науки РФ, лауреат премии Совета Министров СССР.

Главные интересы Хавинсона Владимира Хацкелевича в сфере науки сосредоточены в области клинического изучения процессов старения.

Рыжак Галина Анатольевна — заместитель директора по научной работе и новым технологиям Санкт-Петербургского института биорегуляции и геронтологии Северо-Западного отделения РАМН, Профессор, доктор медицинских наук.
Высококвалифицированный научный специалист в области экспериментального и клинического изучения пептидных геропротекторных средств.

Основным направлением ее исследований является изучение механизмов старения и разработка методов профилактики и коррекции возрастной патологии, основанных на патогенетическом применении пептидных биорегуляторов.

Галина Анатольевна принимала участие в разработке технологии и организации производства 35 фармакологических препаратов и биологически активных добавок, разрешенных Минздравом РФ к медицинскому применению. Автор 98 научных работ.

Научная деятельность

В настоящее время Санкт-Петербургский институт биорегуляции и геронтологии СЗО РАМН является единственным в Северо-Западном регионе научно-исследовательским учреждением, занимающимся разработкой проблем старения и действующим научно-практическим и клинико-диагностическим центром геронтологии и гериатрии.
В структуру Института входят 15 лабораторий, объединенных в три отдела:

биогеронтологии,
клеточной биологии,
патологии, клинической геронтологии и гериатрии.

Все лаборатории оснащены современным оборудованием, позволяющим проводить на высоком методическом уровне экспериментальные и клинические исследования в области генетики, химии, биохимии, иммунологии, физиологии, молекулярной и клеточной биологии, морфологии.
Научно-исследовательская деятельность Института осуществляется по следующим приоритетным направлениям:

изучение механизмов старения;
изучение свойств и механизмов действия пептидных биорегуляторов;
разработка и внедрение в медицинскую практику новых лекарственных препаратов на основе пептидных биорегуляторов;
изучение маркеров прижизненной диагностики заболеваний, ассоциированных с возрастом;
изучение демографических аспектов старения населения.

Институт проводит активную работу по внедрению научных разработок в европейскую и мировую клиническую практику, выполняя 12 научных тем в соответствии с договорами о научном сотрудничестве по приоритетным направлениям с 20 странами. Международное сотрудничество Института представлено широким спектром учреждений и организаций.
Достижения Института защищены 125 патентами, в том числе 40 зарубежными патентами (США, Япония, Швейцария, Австралия и др.), 70 товарными знаками.

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Институт биорегуляции и геронтологии организован в 1992 г. с целью реализации фундаментальных и прикладных задач в области биорегуляции и геронтологии. Одной из целей создания института было внедрение в медицинскую практику результатов 20-летних экспериментальных и клинических исследований нового класса лекарственных препаратов – пептидных биорегуляторов, созданных в научно-исследовательской лаборатории биорегуляторов Военно-медицинской академии МО РФ. По решению Президиума РАМН в 1998 г. Институт включен в состав Северо-Западного отделения РАМН (на условиях самофинансирования).

В Институте организовано 7 лабораторий и 10 научных групп, оснащенных современным оборудованием.

В составе Ученого Совета Института 11 докторов наук (9 докторов медицинских наук, 1 доктор биологических наук, 1 доктор химических наук) и 10 кандидатов наук (7 кандидатов медицинских наук, 2 кандидата биологических наук, 1 кандидат химических наук).

Основные направления научно-исследовательской деятельности института:

Изучение механизмов старения;

Изучение свойств и механизмов действия пептидных биорегуляторов;

Изучение влияния пептидных биорегуляторов на механизмы старения;

Разработка и внедрение в медицинскую практику новых лекарственных препаратов на основе пептидных биорегуляторов;

Изучение генотипа животных и человека с целью совершенствования методов диагностики, прогнозирования и лечения возрастной патологии.

В Институте впервые в мировой медицинской практике разработана для применения новая медицинская технология (биорегулирующая терапия) для восстановления и сохранения основных функций органов и тканей организма в пределах генетически детерминированного срока жизни человека (100-110 лет), основанная на многолетнем опыте научных, биотехнологических и медицинских исследований в области биорегуляции и геронтологии.

В результате проводимых в Институте исследований установлены основные механизмы развития преждевременного старения и разработан способ комплексного применения новых пептидных биорегуляторов для замедления процессов старения и увеличения продолжительности жизни до верхнего видового предела (в эксперименте на 30-40 %).

К настоящему времени в Институте разработаны и находятся на разных стадиях изучения и внедрения три класса биологически активных веществ:

1. Цитомедины (лекарственные препараты) – комплексы полипептидов с молекулярной массой 1000-10000 дальтон, обладающие способностью индуцировать процессы специфической дифференцировки в популяции клеток, являющихся исходным материалом для их получения. Введение цитомединов в организм способствует восстановлению специфических функций органов и тканей в случае их угнетения в результате патологического процесса или при старении. Разрешены к медицинскому применению лекарственные полипептидные препараты Тималин, Эпиталамин, Простатилен, Кортексин, Ретиналамин.

2. Цитамины (биологически активные добавки к пище) – нуклеопротеиновые комплексы, полученные из органов и тканей животных. Являются физиологическими корректорами функций организма и применяются для профилактики различных заболеваний и патологических состояний, а также для замедления процессов старения и повышения качества жизни человека. Промышленный выпуск 17 видов биологически активных добавок к пище организован в России, Германии и Бельгии.

3. Цитогены (лекарственные препараты) – синтетические пептиды. Новый класс биорегуляторов, обладающих высокой тканеспецифической активностью в сверхмалых дозах. Являются физиологическими корректорами функций организма и рекомендуются для профилактики и лечения различных заболеваний и патологических состояний, а также для замедления процессов старения. Синтетический пептидный иммуномодулятор Тимоген, разрешенный к медицинскому применению в России, после получения положительного решения Управления по контролю качества пищевых продуктов и медикаментов (FDA – Food and Drug Administration USA) находится на III стадии клинического изучения в США.

Полученные вещества характеризуются небольшой молекулярной массой и отсутствием видоспецифичности, токсичности и аллергизирующих свойств.

Институт оснащен современным диагностическим и лечебным оборудованием.

В Институте впервые в мировой медицинской практике разработана и внедрена новая система комплексной диагностики, прогнозирования, профилактики и коррекции возрастной патологии. Совместно с ведущими генетиками страны впервые разработана комплексная система диагностики структурной организации 20 генов, позволяющих определить предрасположенность к развитию заболеваний сердечно-сосудистой системы, онкологических заболеваний и характер нарушений обменных и регуляторных процессов. Впервые внедрены в практику схемы профилактики развития генетически детерминированной патологии с использованием пептидных биорегуляторов. Впервые разработан не имеющий аналога в мировой клинической практике способ лечения пептидными биорегуляторами заболеваний сетчатки, ведущих к слепоте.

За этот период обследовано и находилось на лечении около 1500 человек. Эффективность проводимого лечения отмечалась в 96,7% случаев по субъективным показателям состояния здоровья, а в 58,1-81,7% – по объективным показателям.

При активном участии Института биорегуляции и геронтологии в 1994 г. организовано Геронтологическое общество РАН (президентом общества избран профессор В. Н. Анисимов, вице-президентом – профессор В. Х. Хавинсон).

В 1996 г. Институт организовал Международный симпозиум «Геронтологические аспекты пептидной регуляции функций организма», проходивший в Санкт-Петербурге.

Институт проводит научно-исследовательскую работу совместно с ведущими научно-исследовательскими и лечебными учреждениями Москвы, Санкт-Петербурга, Читы, Киева и Харькова.

По результатам экспериментального и клинического изучения пептидных биорегуляторов проведено 4 конференции в России. Специалисты Института выступали с докладами на 10 Международных симпозиумах и конгрессах (Россия, Нидерланды, Австрия, Греция, Румыния, Австралия, Финляндия, Дания, Германия).

Подписаны договоры о международном научном сотрудничестве с Институтом геронтологии АМН Украины (Киев), Итальянским национальным научным центром старения (Анкона), Институтом клинической медицины и терапии Университета г. Пармы (Италия), Институтом современной медицины (Бангкок, Таиланд), Городской больницей Вены (Австрия), лабораторией биологии опухолей медицинского университета Ганновера (Германия), Школой ветеринарной медицины Иерусалимского университета г. Реховота (Израиль).

Институт участвует в подготовке научных и научно-педагогических кадров. В настоящее время выполняются 5 докторских и 9 кандидатских диссертаций.

Результаты многолетних экспериментальных и клинических исследований позволяют сделать вывод о необходимости использования пептидных биорегуляторов в комплексной профилактике возрастной патологии. Создан новый класс гериатрических препаратов, использование которых позволяет эффективно проводить профилактику ускоренного старения, а также лечить заболевания, связанные со старением. Дальнейшее изучение биологически активных веществ, вырабатываемых клетками и тканями организма, открывает новый физиологический путь к замедлению процессов старения и увеличению продолжительности жизни человека.